![]() ![]() This is followed by disappearance of all discomforts giving a false sense of relief followed by progressive hepatic encephalopathy as is evidenced by vomiting, jaundice, hepatic pain, confusion, coma, and coarse flapping tremors of hands (asterixis), gastrointestinal (GI) hemorrhage, cerebral edema, renal tubular necrosis, etc. Initially within the first 24 hours the drug can produce anorexia, nausea, vomiting, and epigastric pain. It can produce severe liver damage due to the accumulation of a highly toxic intermediate metabolite: N-acetyl- p-benzoquinoneimine (NAPQ). It acts by the inhibition of prostaglandin synthesis. Paracetamol (acetaminophen) is a nonnarcotic analgesic and antipyretic. What are the toxic effects of paracetamol? ![]() The most common symptoms of aspirin poisoning include vomiting, flushed face, edema of face, skin rash, tinnitus, deafness, hyperpnea, nausea, hematemesis, hypoprothrombinemia, acute renal failure, pulmonary edema, and respiratory arrest. 143 Histopathological reports following aspirin intoxication are rare, but autopsy results from a 34-year-old woman who had ingested 15 g over 3 days showed centrum semiovale and deep cerebellar white matter myelin damage with preservation of axons. 142 Cerebral dysfunction may include symptoms ranging from confusion to coma. In mild to moderate intoxication, patients may have tinnitus and lethargy however, in severe intoxications, encephalopathy, coma, seizures, and cerebral edema may be seen. 141įew reports exist in the literature regarding neurological manifestations of aspirin and other salicylate intoxication. 141 Onset of symptoms may occur between 1 and 24 hours following aspirin ingestion. 141 Neurological symptoms reported following exposure include tinnitus, lethargy, confusion, and seizures. Of these, 44% involved children younger than 6 years. poison control centers received 40,405 reports of aspirin poisonings in 2004. Kennedy, in Clinical Neurotoxicology, 2009 Intoxication ![]()
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